ASSOCIATION OF GLUCOSE WITH GENERAL AND CARDIOVASCULAR MORTALITY AMONG POPULATION FROM 55 YEARS AND OLDER

Abstract

Aim. To evaluate association of various blood glucose levels with overall and cardiovascular mortality (CVM) among population 55 y. o. and older.Material and methods. Current paper represents partially the prospective study “Stress, ageing and health”. Totally, 1876 participants at the age 55 years and older included, assessed for traditional RF and presence of definite CHD according to quintile stratification by glucose levels in blood: <5,1 mmol/L, 5,1-5,5 mmol/L, 5,51-5,89 mmol/L, 5,9-6,59 mmol/L, >6,59 mmol/L. Epidemiological diagnosis of definite CHD was set based upon the algoritms and questionnaire by Rose and results of ECG by Minnessota coding. Follow-up lasted in average for 7,05 years. Totally, 411 lethal cases registered, among those 247 — from CVD. Statistics was done with STATA software.Results. Relative total risk of death after correction by sex, age and diabetes was significantly higher among those with glucose lower than 5,1 mmol/L. Such relations of glucose and total mortality were significant after correction for sex, age, diabetes, CHD and/or traditional risk factors. Also, the most prominent decrease of morality is found in glucose level 5,51-5,89 mmol/L. However, the highest glucose levels are associated with higher mortality, but not significantly. When assessing impact of glucose on CVM, same associations were found, though not so much significant. Significant relation of CVM was found just for glucose level equal to 5,51-5,89 mmol/L.Conclusion. Association of glucose with overall and CVM in population 55 y. o. and older is L-shaped. The highest overall and CVM is found in persons with glucose <5,1 mmol/L.

Keywords

• blood glucose
• coronary heart disease
• traditional risk factors
• overall mortality
• cardiovascular mortality