Nature Communications (Sep 2017)

Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

  • Sumeet Pal Singh,
  • Sharan Janjuha,
  • Theresa Hartmann,
  • Özge Kayisoglu,
  • Judith Konantz,
  • Sarah Birke,
  • Priyanka Murawala,
  • Ezzaldin Ahmed Alfar,
  • Kei Murata,
  • Anne Eugster,
  • Naoki Tsuji,
  • Edward R. Morrissey,
  • Michael Brand,
  • Nikolay Ninov

DOI
https://doi.org/10.1038/s41467-017-00461-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.