Journal of Inflammation (Mar 2023)
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
- Gaetano Scaramuzzo,
- Francesco Nucera,
- Alessio Asmundo,
- Roberto Messina,
- Matilde Mari,
- Federica Montanaro,
- Matt D. Johansen,
- Francesco Monaco,
- Guido Fadda,
- Giovanni Tuccari,
- Nicole G. Hansbro,
- Philip M. Hansbro,
- Trevor T. Hansel,
- Ian M. Adcock,
- Antonio David,
- Paul Kirkham,
- Gaetano Caramori,
- Carlo Alberto Volta,
- Savino Spadaro
Affiliations
- Gaetano Scaramuzzo
- Department of Translational Medicine, University of Ferrara
- Francesco Nucera
- Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina
- Alessio Asmundo
- Medicina Legale, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina
- Roberto Messina
- Intensive Care Unit, Dipartimento di Patologia Umana e dell’Età Evolutiva Gaetano Barresi, Università di Messina
- Matilde Mari
- Department of Translational Medicine, University of Ferrara
- Federica Montanaro
- Department of Translational Medicine, University of Ferrara
- Matt D. Johansen
- Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney
- Francesco Monaco
- Chirurgia Toracica, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina
- Guido Fadda
- Section of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age “Gaetano Barresi”, University of Messina
- Giovanni Tuccari
- Section of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age “Gaetano Barresi”, University of Messina
- Nicole G. Hansbro
- Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney
- Philip M. Hansbro
- Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney
- Trevor T. Hansel
- Medical Research Council and Asthma, UK Centre in Allergic Mechanisms of Asthma
- Ian M. Adcock
- Airway Disease Section, National Heart and Lung Institute, Imperial College London
- Antonio David
- Intensive Care Unit, Dipartimento di Patologia Umana e dell’Età Evolutiva Gaetano Barresi, Università di Messina
- Paul Kirkham
- Department of Biomedical Sciences, Faculty of Sciences and Engineering, University of Wolverhampton
- Gaetano Caramori
- Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina
- Carlo Alberto Volta
- Department of Translational Medicine, University of Ferrara
- Savino Spadaro
- Department of Translational Medicine, University of Ferrara
- DOI
- https://doi.org/10.1186/s12950-023-00333-2
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 24
Abstract
Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
Keywords
