Radiology Case Reports (Jan 2022)

Uveal melanoma incidentally diagnosed with neuroimaging, a case series of 3 patients

  • Mai Tsukikawa, MD,
  • Babatunde Akinpelu, MD,
  • Pattana Wangaryattawanich, MD,
  • Kathryn Scherpelz, MDPhD,
  • Andrew W. Stacey, MDMS

Journal volume & issue
Vol. 17, no. 1
pp. 54 – 59


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Uveal melanoma is the most common primary intraocular malignancy and can occur in the choroid, the ciliary body, or the iris. It is most often diagnosed based on clinical examination by an ophthalmologist. Nearly all patients present with visual symptoms. Characteristic findings on clinical examination include pigmented or pale choroidal masses with serous retinal detachments and acoustic hollowness seen with ocular ultrasonography. CT and MRI of the orbits are not traditionally utilized for the diagnosis of uveal melanoma. We present 3 cases in which uveal melanoma was an incidental finding on neuroimaging for unrelated conditions in asymptomatic patients. Radiologists should maintain a high suspicion for uveal melanoma when an intraocular mass of greater than 2 mm in thickness is seen on CT or MRI.