Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

Abstract

MCL1, a pro-survival BCL-2 related protein with rapid turnover rate, is often dysregulated in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its inhibition sensitises tumor cells to BH3 mimetic inhibitors.