Nature Communications (Sep 2017)

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

  • Sash Lopaticki,
  • Annie S. P. Yang,
  • Alan John,
  • Nichollas E. Scott,
  • James P. Lingford,
  • Matthew T. O’Neill,
  • Sara M. Erickson,
  • Nicole C. McKenzie,
  • Charlie Jennison,
  • Lachlan W. Whitehead,
  • Donna N. Douglas,
  • Norman M. Kneteman,
  • Ethan D. Goddard-Borger,
  • Justin A. Boddey

DOI
https://doi.org/10.1038/s41467-017-00571-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.