HIV/AIDS: Research and Palliative Care (Nov 2020)
Isolation and Antibiotic Susceptibility Pattern of Bacterial Uropathogens and Associated Factors Among Adult People Living with HIV/AIDS Attending the HIV Center at Wolaita Sodo University Teaching Referral Hospital, South Ethiopia
Abstract
Admasu Haile Hantalo,1 Kassahun Haile Taassaw,1 Fithamlak Solomon Bisetegen,2 Yimtubezenash Woldeamanuel Mulate3 1Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health Sciences, Wolaita Sodo University, Wolaita Sodo, Ethiopia; 3Department of Microbiology, Immunology, Parasitology, School of Medicine, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Admasu Haile HantaloDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, EthiopiaTel +251 926 427 907Email [email protected]: Urinary tract infection remains one of the major public health problems in developing countries, including Ethiopia. Its prevalence is fuelled by human immunodeficiency virus infection which represents a considerable health problem amongst these populations. This study aimed to assess the prevalence, antimicrobial susceptibility pattern and associated factors of bacterial urinary tract infections among adult PLHIV.Methods: Cross-sectional study was conducted from May to December, 2018 among adult people living with HIV/AIDS in Wolaita Sodo University Teaching and Referral Hospital. The socio-demographic data and clinical data were collected using structured questionnaire. Mid-stream urine sample was collected for bacterial isolation and identification. Antimicrobial sensitivity testing was done by Kirby-Bauer disk diffusion technique. Logistic regression was conducted to check the association between UTI and associated factors.Results: The overall prevalence of urinary tract infection was 29 (14.1%). The predominant bacteria isolated was E. coli 13 (44.8%) followed by S. aureus 5 (17.2%). Gender, CD4 count, history of catheterization, history of hospitalization, and DM status were independent factors for the occurrence of urinary tract infection. E. coli species were 100% and 84.6% susceptible to ciprofloxacin and norfloxacin, respectively; whereas, there was a complete resistance to amoxicillin-clavulanic acid and ampicillin. K. pneumoniae was pan resistant to gentamicin, amikacin and ampicillin, whereas 100% sensitive to nitrofurantoin. The rate of MDR was 23 (79.3%) with the majority, 16 (69.6%), gram negative and seven (30.4%) gram positive.Conclusion: The burden of UTI among people living with HIV was considerably high. The findings of this study will help policy makers and other stakeholders as baseline information.Keywords: urinary tract infection, PLHIV, antibiotic susceptibility pattern, Wolaita, Ethiopia
