Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea

Xizhong Song; Xiaoyu Liu; Wei Yu; Yi Jin

doi:10.3390/molecules26216437

Molecules (Oct 2021)

Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea

Xizhong Song,
Xiaoyu Liu,
Wei Yu,
Yi Jin

Affiliations

Xizhong Song: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Xiaoyu Liu: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Wei Yu: 920th Hospital of Joint Logistics Support Force, PLA, Kunming 650118, China
Yi Jin: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China

DOI: https://doi.org/10.3390/molecules26216437
Journal volume & issue: Vol. 26, no. 21
p. 6437

Abstract

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A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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