Predictive Value of Combined Detection of Serum LGALS3BP and GDF-15 for the Prognosis of ICU Sepsis Patients

Abstract

Dengliang Ji,1 Jiulong Li,2 Andong Liu,3 Ruiping Ye,4 Shengrui Zhang,5 Lin Gao,5 Zhenfei Huang5 1Department of Intensive Care Unit, Ganzhou Fifth People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of China; 2Department of Intensive Care Unit, Ningdu County Chinese Medicine Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of China; 3Department of Intensive Care Unit, Suichuan County Chinese Medicine Hospital, Jian, Jiangxi, 343000, People’s Republic of China; 4Department of Intensive Care Unit, Dingnan County First People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of China; 5Department of Intensive Care Unit, GanZhou People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of ChinaCorrespondence: Zhenfei Huang, Department of Intensive Care Unit, GanZhou People’s Hospital, No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, Jiangxi, 341000, People’s Republic of China, Email [email protected]: This study aims to investigate the effectiveness of combining serum lectin galactoside-binding soluble 3 binding protein (LGALS3BP) with growth differentiation factor 15 (GDF-15) for predicting outcomes in sepsis patients in an intensive care unit (ICU) setting.Methods: The study involved 208 sepsis patients from the ICU of our hospital. These patients were categorized based on their 28-day survival outcomes into two groups: 166 in the survival group and 42 in the mortality group. The serum levels of LGALS3BP and GDF-15 were measured using the ELISA technique. Pearson and Spearman methods were utilized for correlation analysis. Factors affecting mortality in ICU sepsis patients were evaluated through multivariate logistic regression analysis. The efficacy of these biomarkers in prognosis prediction was assessed using receiver operating characteristic (ROC) curve analysis.Results: The proportion of septic shock, APACHE II score, SOFA score, and serum LGALS3BP and GDF-15 levels in ICU sepsis patients in the death group were obviously higher than those in the survival group (P 0.05).Conclusion: Serum levels of LGALS3BP and GDF-15 can both be used as predictive indicators for death in ICU sepsis patients, and their combined predictive efficacy is better.Keywords: sepsis, intensive care unit, lectin galactoside-binding soluble 3 binding protein, growth differentiation factor 15, prognosis

Keywords

• sepsis
• intensive care unit
• lectin galactoside-binding soluble 3 binding protein
• growth differentiation factor 15
• prognosis