Bacterial 7-dehydroxylation of cholic acid and allocholic acid

Victor Bokkenheuser; Takahiko Hoshita; Erwin H. Mosbach

doi:10.1016/s0022-2275(20)43070-6

Journal of Lipid Research (Jul 1969)

Bacterial 7-dehydroxylation of cholic acid and allocholic acid

Victor Bokkenheuser,
Takahiko Hoshita,
Erwin H. Mosbach

Affiliations

Victor Bokkenheuser: Department of Microbiology, St. Luke's Hospital Center, New York 10025; The Public Health Research Institute of the City of New York, Inc., New York 10016; and The Bureau of Laboratories, New York City Department of Health, New York 10016; The Public Health Research Institute of the City of New York, Inc., New York 10016;; The Bureau of Laboratories, New York City Department of Health, New York 10016
Takahiko Hoshita: Department of Microbiology, St. Luke's Hospital Center, New York 10025; The Public Health Research Institute of the City of New York, Inc., New York 10016; and The Bureau of Laboratories, New York City Department of Health, New York 10016; The Public Health Research Institute of the City of New York, Inc., New York 10016;; The Bureau of Laboratories, New York City Department of Health, New York 10016
Erwin H. Mosbach: Department of Microbiology, St. Luke's Hospital Center, New York 10025; The Public Health Research Institute of the City of New York, Inc., New York 10016; and The Bureau of Laboratories, New York City Department of Health, New York 10016; The Public Health Research Institute of the City of New York, Inc., New York 10016;; The Bureau of Laboratories, New York City Department of Health, New York 10016

DOI: https://doi.org/10.1016/s0022-2275(20)43070-6
Journal volume & issue: Vol. 10, no. 4
pp. 421 – 426

Abstract

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An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes). The growth of the organism was inhibited by neomycin, 10-20 μg/ml. The existence of this organism affords a satisfactory explanation for the development of gallstones in the cholestanol-fed rabbit and for their absence in rabbits simultaneously treated with neomycin.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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