Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review

Abstract

Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel [phone]Fax [phone]Email [email protected]*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs

Keywords

• pancreatic cancer
• early detection
• circulating microRNAs