Value of nutritional indices in predicting survival free from pump replacement and driveline infections in centrifugal left ventricular assist devicesCentral MessagePerspective
Fabian Jimenez Contreras, MD,
Bret L. Pinsker, MD,
Jason N. Katz, MD, MHS,
Stuart D. Russell, MD,
Jacob Schroder, MD,
Benjamin Bryner, MD,
Alexander H. Gunn, MD,
Krunal Amin, MD,
Carmelo Milano, MD
Affiliations
Fabian Jimenez Contreras, MD
Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC; Fabian Jimenez Contreras, MD, Cardiothoracic Surgery, University of Florida, 1600 SW Archer Rd, P.O. Box 100287, Gainesville, FL 32608.
Bret L. Pinsker, MD
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC; Address for reprints: Bret L. Pinsker, MD, Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Rd, Durham, NC 27710.
Jason N. Katz, MD, MHS
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC
Stuart D. Russell, MD
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC
Jacob Schroder, MD
Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC
Benjamin Bryner, MD
Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC
Alexander H. Gunn, MD
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC
Krunal Amin, MD
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC
Carmelo Milano, MD
Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC
Objective: There is a paucity of data assessing the impact of nutritional status on outcomes in patients supported with the HeartMate 3 (HM3) left ventricular assist device (LVAD). Methods: Patients ≥18 years of age who underwent HM3 LVAD implantation between 2015 and 2020 were identified from a single tertiary care center. The primary outcome assessed was death or device replacement. A secondary outcome of driveline infection was also evaluated. Kaplan-Meier survival analysis and a multivariate Cox-proportional hazards model were used to identify predictors of outcome. Results: Of the 289 patients identified, 94 (33%) experienced a primary outcome and 96 (33%) a secondary outcome during a median follow-up time of 2.3 years. Independent predictors of the primary outcome included peripheral vascular disease (hazard ratio [HR], 3.40; 95% confidence interval [CI], 1.66-6.97, P 33, may be of value in this population.
