Общая реаниматология (Feb 2008)

Impaired NAD+ Metabolism in Neuronal Dysfunction in Critical Conditions

  • A. V Salmina,
  • A. A. Fursov,
  • S. V Mikhutkina,
  • S. V. Shakhmayeva,
  • N. S. Mantorova

DOI
https://doi.org/10.15360/1813-9779-2008-1-80
Journal volume & issue
Vol. 4, no. 1

Abstract

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The present views of the pathogenesis of neuronal dysfunction in critical conditions are analyzed, by taking into account of impairments of cellular NAD+ metabolism, the activity of NAD+-converting enzymes, including ADP-ribosyl cyclase/CD38, the possibilities of developing new neuroprotective strategies. Key words: neuronal dysfunction, ADP-rybosyl cyclase/CD38, NAD+, critical condition.