Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

Marina Vabistsevits; George Davey Smith; Eleanor Sanderson; Tom G. Richardson; Bethan Lloyd-Lewis; Rebecca C. Richmond

doi:10.1038/s42003-022-03272-5

Communications Biology (Apr 2022)

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization

Marina Vabistsevits,
George Davey Smith,
Eleanor Sanderson,
Tom G. Richardson,
Bethan Lloyd-Lewis,
Rebecca C. Richmond

Affiliations

Marina Vabistsevits: Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House
George Davey Smith: Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House
Eleanor Sanderson: Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House
Tom G. Richardson: Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House
Bethan Lloyd-Lewis: School of Cellular and Molecular Medicine, University of Bristol
Rebecca C. Richmond: Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House

DOI: https://doi.org/10.1038/s42003-022-03272-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Previous studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. A Mendelian randomization analysis suggests that the effects of adiposity may remain even when 18 potential mediators are accounted for, suggesting a lack of evidence for mediation and that other mediating pathways remain to be determined.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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