R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations

Harry S. Xenias; Chuyu Chen; Shuo Kang; Suraj Cherian; Xiaolei Situ; Bharanidharan Shanmugasundaram; Guoxiang Liu; Giuseppe Scesa; C. Savio Chan; Loukia Parisiadou

doi:10.1038/s42003-022-04136-8

Communications Biology (Nov 2022)

R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations

Harry S. Xenias,
Chuyu Chen,
Shuo Kang,
Suraj Cherian,
Xiaolei Situ,
Bharanidharan Shanmugasundaram,
Guoxiang Liu,
Giuseppe Scesa,
C. Savio Chan,
Loukia Parisiadou

Affiliations

Harry S. Xenias: Department of Neuroscience, Feinberg School of Medicine, Northwestern University
Chuyu Chen: Department of Pharmacology, Feinberg School of Medicine, Northwestern University
Shuo Kang: Department of Pharmacology, Feinberg School of Medicine, Northwestern University
Suraj Cherian: Department of Neuroscience, Feinberg School of Medicine, Northwestern University
Xiaolei Situ: Department of Pharmacology, Feinberg School of Medicine, Northwestern University
Bharanidharan Shanmugasundaram: Department of Pharmacology, Feinberg School of Medicine, Northwestern University
Guoxiang Liu: Department of Neurology, Feinberg School of Medicine, Northwestern University
Giuseppe Scesa: Department of Pharmacology, Feinberg School of Medicine, Northwestern University
C. Savio Chan: Department of Neuroscience, Feinberg School of Medicine, Northwestern University
Loukia Parisiadou: Department of Pharmacology, Feinberg School of Medicine, Northwestern University

DOI: https://doi.org/10.1038/s42003-022-04136-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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Studies of two mouse models expressing different mutations of the LRRK2 gene, both associated with Parkinson’s disease, reveals distinct alterations at electrochemical, electrophysiological, molecular, and behavioral levels.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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