Differentiation of bone marrow derived mesenchymal stem cells into male germ-like cells in co-culture with testicular cells

Abstract

Objective. Stem cell therapy, specifically, pre-induction of mesenchymal stem cells toward male germ-like cells may be useful in patients with azoospermia. The aim of this study was to evaluate in vitro differentiation of mouse bone marrow-derived mesenchymal stem cells (BMSCs) into male germ-like cells by indirect co-culture with testicular cells in the presence of bone morphogenetic protein 4 (BMP4).

Keywords

• bmscs
• bone morphogenetic protein 4
• indirect co-culture
• stra8
• dazl