Nature Communications (Oct 2020)
Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS
- Ching Serena Kao,
- Rebekah van Bruggen,
- Jihye Rachel Kim,
- Xiao Xiao Lily Chen,
- Cadia Chan,
- Jooyun Lee,
- Woo In Cho,
- Melody Zhao,
- Claudia Arndt,
- Katarina Maksimovic,
- Mashiat Khan,
- Qiumin Tan,
- Michael D. Wilson,
- Jeehye Park
Affiliations
- Ching Serena Kao
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Rebekah van Bruggen
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Jihye Rachel Kim
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Xiao Xiao Lily Chen
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Cadia Chan
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Jooyun Lee
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Woo In Cho
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Melody Zhao
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Claudia Arndt
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Katarina Maksimovic
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Mashiat Khan
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Qiumin Tan
- Department of Cell Biology, University of Alberta
- Michael D. Wilson
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Jeehye Park
- Genetics and Genome Biology Program, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-020-18949-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
MATR3 is an ALS-linked gene. Here the authors describe a mutant MATR3 knockin mouse, which mimics some aspects of early-stage ALS.
