One-Pot Two-Step Synthesis of 2-Aryl benzimidazole <i>N</i>-oxides Using Microwave Heating as a Tool

Abstract

A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification.

Keywords

• microwave heating
• benzimidazole
• benzimidazole <i>n</i>-oxide
• green chemistry