Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa

C. Wiest; G. Tinkhauser; A. Pogosyan; S. He; F. Baig; F. Morgante; A. Mostofi; E.A. Pereira; H. Tan; P. Brown; F. Torrecillos

Neurobiology of Disease (May 2021)

Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa

C. Wiest,
G. Tinkhauser,
A. Pogosyan,
S. He,
F. Baig,
F. Morgante,
A. Mostofi,
E.A. Pereira,
H. Tan,
P. Brown,
F. Torrecillos

Affiliations

C. Wiest: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
G. Tinkhauser: Department of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland
A. Pogosyan: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
S. He: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
F. Baig: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK; Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK
F. Morgante: Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK
A. Mostofi: Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK
E.A. Pereira: Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK
H. Tan: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
P. Brown: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
F. Torrecillos: Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK; Corresponding author at: Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Journal volume & issue: Vol. 152
p. 105287

Abstract

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Finely-tuned gamma (FTG) oscillations can be recorded from cortex or the subthalamic nucleus (STN) in patients with Parkinson's disease (PD) on dopaminergic medication, and have been associated with dyskinesias. When recorded during deep brain stimulation (DBS) on medication the FTG is entrained to half the stimulation frequency. We investigated whether these characteristics are shared off medication by recording local field potentials (LFP) from the STN from externalised DBS leads in 14 PD patients after overnight withdrawal of medication. FTG was induced de-novo by DBS in the absence of dyskinesias in a third of our cohort. The FTG could outlast stimulation or arise only after DBS ceased. FTG frequencies decreased during and across consecutive DBS blocks, but did not shift with changing stimulation frequency off medication. Together with the sustained after-effects this argues against simple entrainment by DBS in the off medication state. We also found significant coherence between STN-LFP and electroencephalogram (EEG) signals at FTG frequencies. We conclude that FTG is a network phenomenon that behaves differently in the off medication state, when it is neither associated with dyskinesias nor susceptible to entrainment.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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