Бюллетень сибирской медицины (Jun 2009)

The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons

  • Ye. V. Сherepkova,
  • I. A. Gribacheva

DOI
https://doi.org/10.20538/1682-0363-2009-3(2)-49-54
Journal volume & issue
Vol. 8, no. 3(2)
pp. 49 – 54

Abstract

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Alleles frequencies and polymorphisms genotypes frequencies of gene DRD4 (VNTR), gene DAT (VNTR), gene 5-HTT (VNTR and ID) and gene OPRM1 (SNP) were investigated at Russian males taking narcotic substances. It was determined that genotype 4/3 occurs only at persons taking narcotic substances, the most often occurring polymorphism of gene DRD4 is genotype 4/4 in all groups. It was detected that the polymorphism of gene DAT at narcotized persons is presented by the high enough part of genotypes 9/10 and 10/10, but in the rest of groups the distribution is the same. At narcotized persons and in the control group, the carriers’ part of genotype I/D of gene 5НТ2А is high. The genotype D/D occurs only at persons taking narcotic substances. The genotype10/10 of gene 5НТ2А occurs more often than in population group, which conforms to the literature data.

Keywords