The evolutionary relationship of S15/NS1RNA binding domains with a similar protein domain pattern - A computational approach

Abstract

RNA binding proteins are involved in many functions, though the majority of them are composed into small RNA binding domains. The S15/NS1 RNA binding domain is a ribosomal S15 and the non-structural NS1 protein. In this study, an attempt was made to find the evolutionarily related protein fold of the S15/NS1 RNA binding domain using structural and sequence-based analysis, and it was found that several protein domain folds similar to this fold. Apart from these, different support vector machine (SVM) based methods were also developed for the analysis of these folds. According to the results of the structure, sequence and SVM-based analysis, several domain folds are evolutionarily related to the S15/NS1 RNA binding domain fold.

Keywords

• S15/NS1 RNA binding Domain
• Support vector machine
• SVM
• PSSM
• Molecular evolution