Nature Communications (Oct 2022)
A scalable platform to discover antimicrobials of ribosomal origin
- Richard S. Ayikpoe,
- Chengyou Shi,
- Alexander J. Battiste,
- Sara M. Eslami,
- Sangeetha Ramesh,
- Max A. Simon,
- Ian R. Bothwell,
- Hyunji Lee,
- Andrew J. Rice,
- Hengqian Ren,
- Qiqi Tian,
- Lonnie A. Harris,
- Raymond Sarksian,
- Lingyang Zhu,
- Autumn M. Frerk,
- Timothy W. Precord,
- Wilfred A. van der Donk,
- Douglas A. Mitchell,
- Huimin Zhao
Affiliations
- Richard S. Ayikpoe
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Chengyou Shi
- Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
- Alexander J. Battiste
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Sara M. Eslami
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Sangeetha Ramesh
- Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
- Max A. Simon
- Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
- Ian R. Bothwell
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Hyunji Lee
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Andrew J. Rice
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Hengqian Ren
- Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
- Qiqi Tian
- Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
- Lonnie A. Harris
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Raymond Sarksian
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Lingyang Zhu
- School of Chemical Sciences NMR Laboratory, University of Illinois at Urbana-Champaign
- Autumn M. Frerk
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Timothy W. Precord
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Wilfred A. van der Donk
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Douglas A. Mitchell
- Department of Chemistry, University of Illinois at Urbana-Champaign
- Huimin Zhao
- Department of Chemistry, University of Illinois at Urbana-Champaign
- DOI
- https://doi.org/10.1038/s41467-022-33890-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Ribosomally synthesized and post-translationally modified peptides are a source of antimicrobials. Here, the authors report a platform for the rapid evaluation and characterization of biosynthetic gene clusters that enables the identification of 30 structurally diverse modified peptides, including three showing antimicrobial activities.
