Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study
Mélina Régy,
Aline Dugravot,
Séverine Sabia,
Aurore Fayosse,
Jean-Francois Mangin,
Marie Chupin,
Clara Fischer,
Vincent Bouteloup,
Carole Dufouil,
Geneviève Chêne,
Claire Paquet,
Bernard Hanseeuw,
Archana Singh-Manoux,
Julien Dumurgier
Affiliations
Mélina Régy
Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; Université catholique de Louvain, Brussels, Belgium; Corresponding author at: Inserm UMR 1153 – EpiAgeing, 10, avenue de Verdun, Paris 75010, France.
Aline Dugravot
Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France
Séverine Sabia
Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; University College London, Department of Epidemiology and Public Health, London, United Kingdom
Aurore Fayosse
Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France
Jean-Francois Mangin
Université Paris-Saclay, CEA, CNRS, CATI, NeuroSpin, Baobab, Gif sur Yvette, France
Marie Chupin
Université Paris-Saclay, CEA, CNRS, CATI, NeuroSpin, Baobab, Gif sur Yvette, France
Clara Fischer
Université Paris-Saclay, CEA, CNRS, CATI, NeuroSpin, Baobab, Gif sur Yvette, France
Vincent Bouteloup
Université de Bordeaux, Bordeaux, France; Pôle de Santé publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC1401-EC, Bordeaux, France
Carole Dufouil
Université de Bordeaux, Bordeaux, France; Pôle de Santé publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC1401-EC, Bordeaux, France
Geneviève Chêne
Université de Bordeaux, Bordeaux, France; Pôle de Santé publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC1401-EC, Bordeaux, France
Claire Paquet
GHU APHP Nord Université de Paris Lariboisiere - Fernand Widal Paris, France; Université de Paris, INSERMU1144, Paris France
Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; University College London, Department of Epidemiology and Public Health, London, United Kingdom
Julien Dumurgier
Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; GHU APHP Nord Université de Paris Lariboisiere - Fernand Widal Paris, France
Data on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examine the association of APOE4 and measures of regional gray matter volumes in cross-sectional analysis and change therein using longitudinal analyses based on two brain MRI performed at baseline and at two-year follow-up. Overall, in analyses adjusted for age, sex, and intracranial volume, the presence of APOE4 was associated with lower total gray matter volume at baseline and with a higher atrophy rate over the follow-up. The hippocampus and entorhinal cortex were the two gray matter regions most associated with APOE4. Further adjustment for cardiovascular risk factors had little impact on these associations. There was an interaction between age, APOE4 status and total brain volume atrophy rate, with evidence of an earlier age at onset of atrophy in hippocampal volume in APOE4 carriers compared to non-carriers. Those results are in accordance with the role of medial temporal structures in the greater risk of dementia observed in people carrying the APOE4 allele.
