Türk Patoloji Dergisi (May 2021)

Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas

  • Gizem ISSIN,
  • Zafer KUCUKODACI,
  • Ismail YILMAZ,
  • Evren ERKUL,
  • Ersin TURAL,
  • Dilaver DEMIREL,
  • Atila GUNGOR,
  • Sukru YILDIRIM

DOI
https://doi.org/10.5146/tjpath.2021.01528
Journal volume & issue
Vol. 37, no. 2
pp. 106 – 114

Abstract

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Objective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction. Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs.

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