Molbank (Feb 2025)

Syntheses of Chiral 2-Oxazolines from Isosorbide Epoxide Derivative

  • Mohammed Kadraoui,
  • Stéphane Guillarme,
  • Christine Saluzzo

DOI
https://doi.org/10.3390/M1966
Journal volume & issue
Vol. 2025, no. 1
p. M1966

Abstract

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Two chiral monooxazolines were synthesized from a secondary amino alcohol, as a key intermediate, isolated in four steps from an isosorbide-derived epoxide. The 2-oxazolines were then obtained through a reaction between this aminoalcohol and an imidate. The new compounds were fully characterized by FTIR, 1H and 13C NMR, and HRMS analyses.

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