Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

Aviv Rom; Liliya Melamed; Noa Gil; Micah Jonathan Goldrich; Rotem Kadir; Matan Golan; Inbal Biton; Rotem Ben-Tov Perry; Igor Ulitsky

doi:10.1038/s41467-019-13075-8

Nature Communications (Nov 2019)

Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

Aviv Rom,
Liliya Melamed,
Noa Gil,
Micah Jonathan Goldrich,
Rotem Kadir,
Matan Golan,
Inbal Biton,
Rotem Ben-Tov Perry,
Igor Ulitsky

Affiliations

Aviv Rom: Department of Biological Regulation, Weizmann Institute of Science
Liliya Melamed: Department of Biological Regulation, Weizmann Institute of Science
Noa Gil: Department of Biological Regulation, Weizmann Institute of Science
Micah Jonathan Goldrich: Department of Biological Regulation, Weizmann Institute of Science
Rotem Kadir: National Institute for Biotechnology in the Negev and Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev
Matan Golan: Department of Molecular Cell Biology, Weizmann Institute of Science
Inbal Biton: Department of Veterinary Resources, Weizmann Institute of Science
Rotem Ben-Tov Perry: Department of Biological Regulation, Weizmann Institute of Science
Igor Ulitsky: Department of Biological Regulation, Weizmann Institute of Science

DOI: https://doi.org/10.1038/s41467-019-13075-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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