Deltamethrin interacts with Culex quinquefasciatus odorant-binding protein: a novel potential resistance mechanism

Rui-xin Shen; Yi-ting Wang; Jia-hong Wu; Ning Zhang; Heng-duan Zhang; Dan Xing; Yan Chen; Chun-xiao Li; Tong-yan Zhao

doi:10.1186/s13071-021-05041-5

Parasites & Vectors (Jan 2022)

Deltamethrin interacts with Culex quinquefasciatus odorant-binding protein: a novel potential resistance mechanism

Rui-xin Shen,
Yi-ting Wang,
Jia-hong Wu,
Ning Zhang,
Heng-duan Zhang,
Dan Xing,
Yan Chen,
Chun-xiao Li,
Tong-yan Zhao

Affiliations

Rui-xin Shen: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology
Yi-ting Wang: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology
Jia-hong Wu: Guizhou Medical University
Ning Zhang: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology
Heng-duan Zhang: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology
Dan Xing: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology
Yan Chen: Guizhou Medical University
Chun-xiao Li: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology
Tong-yan Zhao: State Key Laboratory of Pathogen and Biosecurity, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease, Beijing Institute of Microbiology and Epidemiology

DOI: https://doi.org/10.1186/s13071-021-05041-5
Journal volume & issue: Vol. 15, no. 1
pp. 1 – 9

Abstract

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Highlights 1. RNA sequencing showed that OBP28 gene expression was higher in the deltamethrin-resistant strains. 2. The qPCR results verified that OBP28 gene expression was higher in the resistant strains. 3. RNA interference silenced the OBP28 gene at an efficiency of more than 50%. 4. The sensitivity of Cx. quinquefasciatus to deltamethrin increased after OBP28 had been silenced.

Published in Parasites & Vectors

ISSN: 1756-3305 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://parasitesandvectors.biomedcentral.com/

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Abstract

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