Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress

Abstract

Highlights Male, but not female, pPVT neurons display increases in EPSC amplitude and decay time 24 h following one and five restraints. Input resistance is increased 24 h following one and five restraints in male, but not female, pPVT neurons. Afterhyperpolarization potential is greater in pPVT neurons of females compared to males, regardless of restraint. Restraint alters the expression of 10 voltage-gated ion channel transcripts in the pPVT of females, but only 3 in males.