Frontiers in Medicine (Mar 2022)

Age-Associated Risk of Liver-Related Adverse Drug Reactions

  • Yan-zhong Han,
  • Yan-zhong Han,
  • Yu-ming Guo,
  • Peng Xiong,
  • Fei-lin Ge,
  • Jing Jing,
  • Ming Niu,
  • Xu Zhao,
  • Zhao-fang Bai,
  • Hai-bo Song,
  • Xiao-he Xiao,
  • Jia-bo Wang,
  • Jia-bo Wang

DOI
https://doi.org/10.3389/fmed.2022.832557
Journal volume & issue
Vol. 9

Abstract

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ObjectiveAging population is generally considered more sensitive to adverse drug reactions (ADRs). Yet, big data-based quantitative evidence currently does not exist to support this concept. This study aims to investigate age-associated risks of liver-related ADR (L-ADR).MethodsSpontaneous reporting data from 2012 to 2016 were retrieved from the China National ADR Monitoring System. The risk ratio (RR) was used to quantify the relative risk of L-ADR of each age group. The reporting odds ratio (ROR) was used to quantify the correlation with the risk of L-ADR of each drug category or drug in older adults.ResultsTotally, 64,702 L-ADR reports were retrieved, covering ages from 1 to 116, with a median age of 49. The RR values increased exponentially with the increase of age, which indicates that the relative risk of L-ADR increased by 33% for every 10-year increase in age. The age cutoff point for relative high risk of L-ADR was estimated at 52.0 years old (RR = 1). In 17 categories composed of 270 drugs, the top 3 drug categories with a high correlation to the risk of L-ADR in older adults were antiarrhythmic (ROR, 5.75; 95% CI: 4.45–7.42), antilipemic (ROR, 4.77; 95% CI: 4.53–5.02), and antihypertensive (ROR, 2.97; 95% CI: 2.59–3.41).ConclusionsThis research illustrates quantitatively that aging is a potential risk factor for L-ADR, with a 33% increase in relative risk for every 10-year increase in age. Risk management should be addressed for older adults when those drugs with a high correlation to the risk of L-ADR are used.

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