Journal of Asthma and Allergy (Jan 2021)
The Role of Heat Shock Protein 70 kDa in Asthma
Abstract
Marina Shevchenko,1 Ekaterina Servuli,1,2 Zarema Albakova,1,3 Leonid Kanevskiy,1 Alexander Sapozhnikov1,3 1Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; 2Department of Experimental Physiology, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia; 3Department of Biology, Lomonosov Moscow State University, Moscow, RussiaCorrespondence: Marina ShevchenkoDepartment of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, Moscow 117997, RussiaTel/Fax +74953304011Email [email protected]: Asthma is a complex chronic disorder of the airways, affecting immune and structural cells and inducing both protein and tissue remodeling. Heat shock proteins 70 kDa (HSP70s) are highly conserved members of the stress-induced family, possessing precisely described chaperone activity. There is growing evidence of a tight relationship between inflammatory diseases of different origins and the elevation of local HSP70 expression and secretion. Although extracellular HSP70 does not serve as a common marker of asthma, elevated HSP70 levels have been detected in the peripheral blood serum and sputum of patients with asthma, as well as in the bronchoalveolar lavage fluid of mice with induced allergic airway inflammation. Possessing diverse immunomodulating properties, extracellular HSP70 can manifest different activities in airway inflammatory processes and asthma, acting either as a pro-inflammatory trigger, or an anti-inflammatory agent. This review will discuss the effects and possible mechanisms concerning HSP70 implication in airway inflammation regulation in asthma. We examine ATPase and chaperone activities of HSP70 as potential modulators of immune responses in asthma. Given the crucial role of a chronic inflammatory response in asthma, understanding the effects of HSP70 on immune and structural cells may reveal new perspectives for the therapeutic control of inflammation.Keywords: heat shock protein 70 kDa, asthma, allergic airway inflammation, immune cells, ATP
