Anal human papillomavirus (HPV) disagreement by Linear Array compared to SPF10 PCR-DEIA-LiPA25 system in young sexual minority men
Trisha L. Amboree,
Jacky Kuo,
Bradley A. Sirak,
John A. Schneider,
Alan G. Nyitray,
Lu-Yu Hwang,
Elizabeth Y. Chiao,
Anna R. Giuliano,
Kayo Fujimoto
Affiliations
Trisha L. Amboree
Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA; Department of Pediatrics, Center for Epidemiology and Population Health, Baylor College of Medicine, 6620 Main St., Houston, TX, 77030, USA
Jacky Kuo
Department of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston School of Public Health, 7000 Fannin St., Houston, TX, 77030, USA
Bradley A. Sirak
Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
John A. Schneider
Department of Medicine, University of Chicago, 5837 S. Maryland Ave, Chicago, IL, 60637, USA; Chicago Center for HIV Elimination, University of Chicago, 5837 S. Maryland Ave, Chicago, IL, 60637, USA
Alan G. Nyitray
Center for AIDS Intervention Research, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA; Clinical Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA
Lu-Yu Hwang
Center of Infectious Diseases, Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, 1200 Pressler St., Houston, TX, 77030, USA
Elizabeth Y. Chiao
The University of Texas MD Anderson Cancer Center, Departments of Epidemiology and Medical Oncology, 1515 Holcombe Blvd., Houston, TX, 77030, USA
Anna R. Giuliano
Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
Kayo Fujimoto
Department of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston School of Public Health, 7000 Fannin St., Houston, TX, 77030, USA; Corresponding author. 7000 Fannin St., Houston, TX, 77030 USA.
Introduction: Young sexual minority men (SMM) bear the greatest burden of anal human papillomavirus (HPV) infections. We assessed anal HPV genotype discordance between the Linear Array (LA) and SPF10 PCR-DEIA-LiPA25 (LiPA25). Methods: Discordance was assessed between LA and LiPA25 using self-collected anal swabs from 120 SMM aged 18–29 who were recruited in 2014–2016. Multiple-type infection was explored as a potential confounder of testing agreement, along with clinical and behavioral factors such as HIV status, syphilis status, incarceration history, health insurance coverage, having 3 or more sex partners in the past 6 months, and co-infection with HPV-16. Results: Significant discordance was found for HPV-6, -11, -16, -31, -42, -54, and -59. Exploratory analyses suggest higher prevalence of genotype discordance in those living with HIV, those with 3 or more sex partners, and those who were positive for 4 or more HPV types. Conclusions: Our results highlight the importance of HPV detection methods which may inform different interpretations of research assessing anal HPV natural history among SMM at highest risk for HPV.
