Second generation of soluble transferrin receptor assay – consequences for the interpretation of the ‘Thomas plot’

Abstract

The ‘Thomas plot’ is a very helpful diagnostic tool for evaluation, monitoring and therapy of the iron status and on the hemoglobinization of the reticulocytes of patients. In 2021 Roche Diagnostics launched a second generation assay for determination of the soluble transferrin receptor (sTfR). Here we compare the old and the new assay for sTfR and analyze the consequences for the ‘Thomas plot’.

Keywords

• anemia
• iron status
• thomas plot
• soluble transferrin receptor