A case report of a child with Wolcott-Rallison syndrome

Abstract

Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder. It is characterized by neonatal/ early onset non-autoimmune insulin dependent diabetes (permanent neonatal diabetes mellitus-PNDM) associated with spondyloepiphyseal dysplasia, tendency to skeletal fractures and growth retardation. We report a child with features of WRS, born to consanguineous parents and with an older sister having similar clinical features.

Keywords

• wolcott-rallison syndrome (wrs)
• permanent neonatal diabetes mellitus (pndm)
• consanguinity
• skeletal dysplasia
• liver failure
• neutropaenia