The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome

Abstract

Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of diabetic rats with acute morphine withdrawal syndrome. Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight: 1) diabetes control, 2) morphine + diabetes, 3) diabetes + moderate-intensity endurance training, and 4) morphine + diabetes + moderate-intensity endurance training. Diabetes was induced and morphine was administered to create the acute morphine withdrawal syndrome. The training groups underwent an eight-week endurance training protocol. Oxidant and antioxidant indices, including MDA, TAC, GPX, and SOD, were measured in the testicular tissue at the end of the study. Results: The concentration of the oxidant index MDA significantly increased in the diabetes group compared to the other groups (P=0.001). However, moderate-intensity endurance training led to a significant decrease in MDA concentration (P=0.001) and a significant increase in the levels of antioxidant indices (TAC, GPX, and SOD) compared to the diabetes group (P=0.001). Conclusion: Moderate-intensity endurance training could reduce the oxidant index and increase antioxidant indices in the testicular tissue of diabetic rats with morphine withdrawal syndrome. This suggests a potential reduction in infertility complications in these rats.

Keywords

• moderate-intensity endurance training
• diabetes
• morphine
• antioxidant indicators
• malondialdehyde