Meroterpenoids with Immunosuppressive Activity from Edible Fungus <i>Craterellus odoratus</i>
Quan Dai,
Li-Ting Pang,
Fa-Lei Zhang,
Gang-Qiang Wang,
Xue-Mei Li,
Ji-Kai Liu,
Tao Feng
Affiliations
Quan Dai
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China
Li-Ting Pang
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China
Fa-Lei Zhang
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China
Gang-Qiang Wang
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology, Xianning 437100, China
Xue-Mei Li
Plant Protection and Quarantine Station of Dehong, Dehong 678400, China
Ji-Kai Liu
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China
Tao Feng
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China
Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound 1 possessed a rare structure with two aromatic groups. Compounds 1 and 3 showed immunosuppressive activity with IC50 values ranging from 5.516 to 19.953 μM.
