Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis

Chiharu Kimura-Yoshida; Kyoko Mochida; Masa-aki Nakaya; Takeomi Mizutani; Isao Matsuo

doi:10.1038/s41467-018-06171-8

Nature Communications (Oct 2018)

Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis

Chiharu Kimura-Yoshida,
Kyoko Mochida,
Masa-aki Nakaya,
Takeomi Mizutani,
Isao Matsuo

Affiliations

Chiharu Kimura-Yoshida: Department of Molecular Embryology, Research Institute, Osaka Women’s and Children’s Hospital
Kyoko Mochida: Department of Molecular Embryology, Research Institute, Osaka Women’s and Children’s Hospital
Masa-aki Nakaya: Department of Molecular Biology, Yokohama City University Graduate School of Medicine
Takeomi Mizutani: Department of Life Science and Technology, Faculty of Engineering, Hokkai-Gakuen University
Isao Matsuo: Department of Molecular Embryology, Research Institute, Osaka Women’s and Children’s Hospital

DOI: https://doi.org/10.1038/s41467-018-06171-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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