Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

Keisuke Migita; Yu Matsuzaki; Kohei Koga; Taichi Matsumoto; Kenichi Mishima; Shuji Hara; Kenji Honda

Journal of Pharmacological Sciences (Jun 2018)

Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

Keisuke Migita,
Yu Matsuzaki,
Kohei Koga,
Taichi Matsumoto,
Kenichi Mishima,
Shuji Hara,
Kenji Honda

Affiliations

Keisuke Migita: Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan; Corresponding author. Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jounan-ku, Fukuoka, 814-0180, Japan. Fax: +81 92 863 0389.
Yu Matsuzaki: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan
Kohei Koga: Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan
Taichi Matsumoto: Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan
Kenichi Mishima: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan
Shuji Hara: Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan
Kenji Honda: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan; Corresponding author. Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jounan-ku, Fukuoka, 814-0180, Japan. Fax: +81 92 863 0389.

Journal volume & issue: Vol. 137, no. 2
pp. 233 – 236

Abstract

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The role of the GABAB receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABAB receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats. Activation of the GABAB receptor injected by a GABAB receptor agonist baclofen into the ACC attenuated mechanical hypersensitivity in partial sciatic nerve ligation (PSNL) rats. Co-microinjection of CGP35348 with a muscarinic M1 receptor agonist McN-A-343 into the ACC significantly inhibited McN-A-343-induced antihypersensitivity in PSNL rats. These results suggest that the GABAB receptor in the ACC contributes to mechanical hypersensitivity and is involved in muscarinic M1 receptor-mediated antihypersensitivity. Keywords: GABAB receptor, Anterior cingulate cortex, Partial sciatic nerve ligation model

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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