First dose COVID-19 vaccine coverage amongst adolescents and children in England: an analysis of 3.21 million patients' primary care records in situ using OpenSAFELY [version 2; peer review: 2 approved]

Frank Hester; John Parry; Sam Harper; Colm D. Andrews; Christopher Bates; Peter Inglesby; Alex J. Walker; Lisa E. Hopcroft; Laurie A. Tomlinson; Helen J. Curtis; Sebastian C. Bacon; Andrew D. Brown; Caroline E. Morton; Viyaasan Mahalingasivam; Rosalind M. Eggo; Edward P. K. Parker; William J. Hulme; Ben Goldacre; Brian MacKenna; Jonathan Cockburn; Jessica Morley; Amir Mehrkar

Wellcome Open Research (Jun 2023)

First dose COVID-19 vaccine coverage amongst adolescents and children in England: an analysis of 3.21 million patients' primary care records in situ using OpenSAFELY [version 2; peer review: 2 approved]

Frank Hester,
John Parry,
Sam Harper,
Colm D. Andrews,
Christopher Bates,
Peter Inglesby,
Alex J. Walker,
Lisa E. Hopcroft,
Laurie A. Tomlinson,
Helen J. Curtis,
Sebastian C. Bacon,
Andrew D. Brown,
Caroline E. Morton,
Viyaasan Mahalingasivam,
Rosalind M. Eggo,
Edward P. K. Parker,
William J. Hulme,
Ben Goldacre,
Brian MacKenna,
Jonathan Cockburn,
Jessica Morley,
Amir Mehrkar

Affiliations

Frank Hester: TPP, TPP House, 129 Low Lane, ,Horsforth, Leeds, LS18 5PX, UK
John Parry: ORCiD; TPP, TPP House, 129 Low Lane, ,Horsforth, Leeds, LS18 5PX, UK
Sam Harper: TPP, TPP House, 129 Low Lane, ,Horsforth, Leeds, LS18 5PX, UK
Colm D. Andrews: ORCiD; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Christopher Bates: TPP, TPP House, 129 Low Lane, ,Horsforth, Leeds, LS18 5PX, UK
Peter Inglesby: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Alex J. Walker: ORCiD; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Lisa E. Hopcroft: ORCiD; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Laurie A. Tomlinson: ORCiD; London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK
Helen J. Curtis: ORCiD; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Sebastian C. Bacon: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Andrew D. Brown: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Caroline E. Morton: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Viyaasan Mahalingasivam: London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK
Rosalind M. Eggo: ORCiD; London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK
Edward P. K. Parker: London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK
William J. Hulme: ORCiD; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Ben Goldacre: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Brian MacKenna: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Jonathan Cockburn: TPP, TPP House, 129 Low Lane, ,Horsforth, Leeds, LS18 5PX, UK
Jessica Morley: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK
Amir Mehrkar: Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK

Journal volume & issue: Vol. 8

Abstract

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Background: The coronavirus disease 2019 (COVID-19) vaccination programme in England was extended to include all adolescents and children by April 2022. The aim of this paper is to describe trends and variation in vaccine coverage in different clinical and demographic groups amongst adolescents and children in England by August 2022. Methods: With the approval of NHS England, a cohort study was conducted of 3.21 million children and adolescents’ records in general practice in England, in situ and within the infrastructure of the electronic health record software vendor TPP using OpenSAFELY. Vaccine coverage across various demographic (sex, deprivation index and ethnicity) and clinical (risk status) populations is described. Results: Coverage is higher amongst adolescents than it is amongst children, with 53.5% adolescents and 10.8% children having received their first dose of the COVID-19 vaccine. Within those groups, coverage varies by ethnicity, deprivation index and risk status; there is no evidence of variation by sex. Conclusion: First dose COVID-19 vaccine coverage is shown to vary amongst various demographic and clinical groups of children and adolescents.

Published in Wellcome Open Research

ISSN: 2398-502X (Online)
Publisher: Wellcome
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://wellcomeopenresearch.org/

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