Data on social transmission of food preference in a model of autism induced by valproic acid and translational analysis of circulating microRNA
Mauro Mozael Hirsch,
Iohanna Deckmann,
Mellanie Fontes-Dutra,
Guilherme Bauer-Negrini,
Gustavo Della-Flora Nunes,
Walquiria Nunes,
Bruna Rabelo,
Rudimar Riesgo,
Rogerio Margis,
Victorio Bambini-Junior,
Carmem Gottfried
Affiliations
Mauro Mozael Hirsch
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; Corresponding authors at: Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil.
Iohanna Deckmann
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil
Mellanie Fontes-Dutra
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil
Guilherme Bauer-Negrini
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil
Gustavo Della-Flora Nunes
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil
Walquiria Nunes
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil
Bruna Rabelo
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil
Rudimar Riesgo
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; Child Neurology Unit, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Rogerio Margis
Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; Center of Biotechnology and PPGBCM, Laboratory of Genomes and Plant Populations, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil
Victorio Bambini-Junior
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK
Carmem Gottfried
Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil; Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; Corresponding authors at: Translational Group in Autism Spectrum Disorder - GETTEA, Clinical Hospital of Porto Alegre, RS, Brazil.
This article contains data of Social Transmission of Food Preference in an animal model of autism and the evaluation of a set of microRNA analyzed in autistic patients and animal model of autism. The analyses of the absolute consumption of two flavored food by male rats prenatally exposed to valproic acid (VPA) and treated with resveratrol (RSV), showed that VPA animals show a trend to eat less of the flavored food presented by a demonstrator rat. We also identified 13 microRNA with similar levels among rodents’ experimental groups, as well as 11 microRNA with no alterations between autistic and control subjects. Further evaluation of mechanisms of VPA and RSV actions on behavioral and molecular alterations can shed light in important biomarkers and etiological triggers of autistic spectrum disorders. Keywords: Autism, Social transmission of food preference, microRNA, Resveratrol, Translational research, Preclinical models, Valproate
