Nature Communications (Nov 2022)
von Willebrand factor links primary hemostasis to innate immunity
- Clive Drakeford,
- Sonia Aguila,
- Fiona Roche,
- Karsten Hokamp,
- Judicael Fazavana,
- Mariana P. Cervantes,
- Annie M. Curtis,
- Heike C. Hawerkamp,
- Sukhraj Pal Singh Dhami,
- Hugo Charles-Messance,
- Emer E. Hackett,
- Alain Chion,
- Soracha Ward,
- Azaz Ahmad,
- Ingmar Schoen,
- Eamon Breen,
- Joe Keane,
- Ross Murphy,
- Roger J. S. Preston,
- Jamie M. O’Sullivan,
- Frederick J. Sheedy,
- Padraic Fallon,
- James S. O’Donnell
Affiliations
- Clive Drakeford
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Sonia Aguila
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Fiona Roche
- Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, College Green
- Karsten Hokamp
- Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, College Green
- Judicael Fazavana
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Mariana P. Cervantes
- School of Pharmacy and Biomolecular Science (PBS) and Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland
- Annie M. Curtis
- School of Pharmacy and Biomolecular Science (PBS) and Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland
- Heike C. Hawerkamp
- School of Medicine, Trinity College Dublin
- Sukhraj Pal Singh Dhami
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Hugo Charles-Messance
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Emer E. Hackett
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Alain Chion
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Soracha Ward
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Azaz Ahmad
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Ingmar Schoen
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Eamon Breen
- Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin
- Joe Keane
- School of Medicine, Trinity College Dublin
- Ross Murphy
- Department of Cardiology, St James’s Hospital
- Roger J. S. Preston
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Jamie M. O’Sullivan
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- Frederick J. Sheedy
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Padraic Fallon
- School of Medicine, Trinity College Dublin
- James S. O’Donnell
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Science (PBS), Royal College of Surgeons in Ireland
- DOI
- https://doi.org/10.1038/s41467-022-33796-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses.
