Nature Communications (Jul 2019)
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
- Qifeng Han,
- Julia A. Jones,
- Nathan I. Nicely,
- Rachel K. Reed,
- Xiaoying Shen,
- Katayoun Mansouri,
- Mark Louder,
- Ashley M. Trama,
- S. Munir Alam,
- Robert J. Edwards,
- Mattia Bonsignori,
- Georgia D. Tomaras,
- Bette Korber,
- David C. Montefiori,
- John R. Mascola,
- Michael S. Seaman,
- Barton F. Haynes,
- Kevin O. Saunders
Affiliations
- Qifeng Han
- Department of Medicine, Duke University Medical Center
- Julia A. Jones
- Department of Medicine, Duke University Medical Center
- Nathan I. Nicely
- Department of Medicine, Duke University Medical Center
- Rachel K. Reed
- Department of Medicine, Duke University Medical Center
- Xiaoying Shen
- Department of Medicine, Duke University Medical Center
- Katayoun Mansouri
- Duke Human Vaccine Institute, Duke University Medical Center
- Mark Louder
- Vaccine Research Center, National Instiftute of Allergy and Infectious Diseases (NIAID), NIH
- Ashley M. Trama
- Department of Medicine, Duke University Medical Center
- S. Munir Alam
- Department of Medicine, Duke University Medical Center
- Robert J. Edwards
- Duke Human Vaccine Institute, Duke University Medical Center
- Mattia Bonsignori
- Department of Medicine, Duke University Medical Center
- Georgia D. Tomaras
- Duke Human Vaccine Institute, Duke University Medical Center
- Bette Korber
- Los Alamos National Laboratory
- David C. Montefiori
- Duke Human Vaccine Institute, Duke University Medical Center
- John R. Mascola
- Vaccine Research Center, National Instiftute of Allergy and Infectious Diseases (NIAID), NIH
- Michael S. Seaman
- Center for Virology and Vaccine Research, Israel Deaconess Medical Center
- Barton F. Haynes
- Department of Medicine, Duke University Medical Center
- Kevin O. Saunders
- Duke Human Vaccine Institute, Duke University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-10899-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting can bias the estimation of vaccine-induced bnAbs.
