Altered differentiation of endometrial mesenchymal stromal fibroblasts is associated with endometriosis susceptibility

Brett D. McKinnon; Samuel W. Lukowski; Sally Mortlock; Joanna Crawford; Sharat Atluri; Sugarniya Subramaniam; Rebecca L. Johnston; Konstantinos Nirgianakis; Keisuke Tanaka; Akwasi Amoako; Michael D. Mueller; Grant W. Montgomery

doi:10.1038/s42003-022-03541-3

Communications Biology (Jun 2022)

Altered differentiation of endometrial mesenchymal stromal fibroblasts is associated with endometriosis susceptibility

Brett D. McKinnon,
Samuel W. Lukowski,
Sally Mortlock,
Joanna Crawford,
Sharat Atluri,
Sugarniya Subramaniam,
Rebecca L. Johnston,
Konstantinos Nirgianakis,
Keisuke Tanaka,
Akwasi Amoako,
Michael D. Mueller,
Grant W. Montgomery

Affiliations

Brett D. McKinnon: Department of Obstetrics and Gynaecology, University Hospital of Berne
Samuel W. Lukowski: The Institute for Molecular Bioscience, The University of Queensland
Sally Mortlock: The Institute for Molecular Bioscience, The University of Queensland
Joanna Crawford: The Institute for Molecular Bioscience, The University of Queensland
Sharat Atluri: The Institute for Molecular Bioscience, The University of Queensland
Sugarniya Subramaniam: The Institute for Molecular Bioscience, The University of Queensland
Rebecca L. Johnston: The Institute for Molecular Bioscience, The University of Queensland
Konstantinos Nirgianakis: Department of Obstetrics and Gynaecology, University Hospital of Berne
Keisuke Tanaka: Department of Gynaecology, Royal Brisbane and Women’s Hospital
Akwasi Amoako: Department of Gynaecology, Royal Brisbane and Women’s Hospital
Michael D. Mueller: Department of Obstetrics and Gynaecology, University Hospital of Berne
Grant W. Montgomery: The Institute for Molecular Bioscience, The University of Queensland

DOI: https://doi.org/10.1038/s42003-022-03541-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

Comparing single cell transcriptome data to clinical characteristics and in vitro growth profiles uncovers a potential role for divergent mesenchymal-derived stromal fibroblast maturation in endometriosis susceptibility.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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