Nature Communications (Jun 2021)
TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
- Yu-chi Shen,
- Adrienne Niederriter Shami,
- Lindsay Moritz,
- Hailey Larose,
- Gabriel L. Manske,
- Qianyi Ma,
- Xianing Zheng,
- Meena Sukhwani,
- Michael Czerwinski,
- Caleb Sultan,
- Haolin Chen,
- Stephen J. Gurczynski,
- Jason R. Spence,
- Kyle E. Orwig,
- Michelle Tallquist,
- Jun Z. Li,
- Saher Sue Hammoud
Affiliations
- Yu-chi Shen
- Department of Human Genetics, University of Michigan
- Adrienne Niederriter Shami
- Department of Human Genetics, University of Michigan
- Lindsay Moritz
- Cellular and Molecular Biology Program, University of Michigan
- Hailey Larose
- Department of Human Genetics, University of Michigan
- Gabriel L. Manske
- Cellular and Molecular Biology Program, University of Michigan
- Qianyi Ma
- Department of Human Genetics, University of Michigan
- Xianing Zheng
- Department of Human Genetics, University of Michigan
- Meena Sukhwani
- Department of Obstetrics, Gynecology and Reproductive Sciences, Integrative Systems Biology Graduate Program, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
- Michael Czerwinski
- Department of Internal Medicine, University of Michigan
- Caleb Sultan
- Department of Human Genetics, University of Michigan
- Haolin Chen
- Biochemistry and Molecular Biology, Bloomberg School of Public Health
- Stephen J. Gurczynski
- Department of Internal Medicine, University of Michigan
- Jason R. Spence
- Department of Internal Medicine, University of Michigan
- Kyle E. Orwig
- Department of Obstetrics, Gynecology and Reproductive Sciences, Integrative Systems Biology Graduate Program, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
- Michelle Tallquist
- University of Hawaii, Center for Cardiovascular Research
- Jun Z. Li
- Department of Human Genetics, University of Michigan
- Saher Sue Hammoud
- Department of Human Genetics, University of Michigan
- DOI
- https://doi.org/10.1038/s41467-021-24130-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Whether the adult testis harbours a somatic progenitor population is unknown. Here, the authors provide evidence that the testis interstitial cells expressing the transcription factor Tcf21 maintain adult testis homeostasis during aging, and act as potential reserve somatic progenitors following injury.
