Frontiers in Plant Science (Oct 2024)
Terahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens
- Yang Gao,
- Yang Gao,
- Yang Gao,
- Yang Gao,
- Zhuang Peng,
- Zhuang Peng,
- Zhuang Peng,
- Zhuang Peng,
- Huiyu Yang,
- Huiyu Yang,
- Huiyu Yang,
- Huiyu Yang,
- Xinrui Zhang,
- Xinrui Zhang,
- Xinrui Zhang,
- Xinrui Zhang,
- Yuhan Zhao,
- Yuhan Zhao,
- Yuhan Zhao,
- Yuhan Zhao,
- Zeyu Hou,
- Zeyu Hou,
- Zeyu Hou,
- Zeyu Hou,
- Bo Su,
- Bo Su,
- Bo Su,
- Bo Su,
- Kai Li,
- Kai Li,
- Kai Li,
- Cunlin Zhang,
- Cunlin Zhang,
- Cunlin Zhang
Affiliations
- Yang Gao
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Yang Gao
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Yang Gao
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Yang Gao
- Department of Physics, Capital Normal University, Beijing, China
- Zhuang Peng
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Zhuang Peng
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Zhuang Peng
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Zhuang Peng
- Department of Physics, Capital Normal University, Beijing, China
- Huiyu Yang
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Huiyu Yang
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Huiyu Yang
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Huiyu Yang
- Department of Physics, Capital Normal University, Beijing, China
- Xinrui Zhang
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Xinrui Zhang
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Xinrui Zhang
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Xinrui Zhang
- Department of Physics, Capital Normal University, Beijing, China
- Yuhan Zhao
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Yuhan Zhao
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Yuhan Zhao
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Yuhan Zhao
- Department of Physics, Capital Normal University, Beijing, China
- Zeyu Hou
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Zeyu Hou
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Zeyu Hou
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Zeyu Hou
- Department of Physics, Capital Normal University, Beijing, China
- Bo Su
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Bo Su
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Bo Su
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Bo Su
- Department of Physics, Capital Normal University, Beijing, China
- Kai Li
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Kai Li
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- Kai Li
- Department of Physics, Capital Normal University, Beijing, China
- Cunlin Zhang
- Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China
- Cunlin Zhang
- Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Capital Normal University, Beijing, China
- Cunlin Zhang
- Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China
- DOI
- https://doi.org/10.3389/fpls.2024.1460123
- Journal volume & issue
-
Vol. 15
Abstract
Rabdosia rubescens, a Chinese herbal medicine with anticancer properties, contains two active ingredients: oridonin and ponicidin. Both compounds exhibit antitumor effects by inducing tumor cell apoptosis and autophagy and inhibiting tumor cell proliferation. To further explore the differences in molecular structure and pharmacological properties between the two substances, this study employs Terahertz Time-Domain Spectroscopy (THz-TDS) to investigate the spectral characteristics of oridonin and ponicidin in the frequency range of 0.1 to 2.3 THz. The crystal structures of the two substances are simulated using Materials Studio software and Density Functional Theory (DFT), yielding their spectra and molecular vibration modes, which elucidate the mechanism underlying the peak generation. The consistency between experimental and simulation results confirms the reliability of the experimental findings. Thus, THz spectroscopy can effectively distinguish between these two substances. Finally, a THz detection is performed on Rabdosia rubescens capsules purchased from the market, revealing the presence of absorption peaks for both substances in their absorption spectra. This provides a new approach for detecting active ingredients in Chinese herbal medicines.
Keywords
