Unsaturated Fatty Acid 10H2DA Content in Serbian Royal Jelly and Its Effects on Motility of Colorectal Carcinoma Cell Lines

Milena M. Jovanović; Dragana S. Šeklić; Milena D. Vukić; Nenad L. Vuković; Nevena S. Planojević; Snežana D. Marković

doi:10.3390/ecsoc-25-11636

Chemistry Proceedings (Nov 2021)

Unsaturated Fatty Acid 10H2DA Content in Serbian Royal Jelly and Its Effects on Motility of Colorectal Carcinoma Cell Lines

Milena M. Jovanović,
Dragana S. Šeklić,
Milena D. Vukić,
Nenad L. Vuković,
Nevena S. Planojević,
Snežana D. Marković

Affiliations

Milena M. Jovanović: Department for Biology and Ecology, Faculty of Science, Radoja Domanovića 12, University of Kragujevac, 34000 Kragujevac, Serbia
Dragana S. Šeklić: Department of Natural Sciences, Institute for Information Technologies Kragujevac, Jovana Cvijića bb, University of Kragujevac, 34000 Kragujevac, Serbia
Milena D. Vukić: Department for Chemistry, Faculty of Science, Radoja Domanovića 12, University of Kragujevac, 34000 Kragujevac, Serbia
Nenad L. Vuković: Department for Chemistry, Faculty of Science, Radoja Domanovića 12, University of Kragujevac, 34000 Kragujevac, Serbia
Nevena S. Planojević: Department for Biology and Ecology, Faculty of Science, Radoja Domanovića 12, University of Kragujevac, 34000 Kragujevac, Serbia
Snežana D. Marković: Department for Biology and Ecology, Faculty of Science, Radoja Domanovića 12, University of Kragujevac, 34000 Kragujevac, Serbia

DOI: https://doi.org/10.3390/ecsoc-25-11636
Journal volume & issue: Vol. 8, no. 1
p. 49

Abstract

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Royal jelly (RJ) is natural bee product with multiple medicinal properties that have been mainly attributed to its active compound fatty acid 10H2DA. Herein, we determined its content in RJ sampled in Serbia, and analyzed its anti-migratory activity on colorectal carcinoma cells. This is the first report of the 10H2DA concentration in Serbian RJ, which is 0.92%. This acid was potent in inhibiting the motility of very aggressive HCT-116 cell line in dose-dependent manner. Further studies are needed to be conducted, especially more detailed research regarding application of this natural product compound as complementary drug in anti-cancer treatment.

Published in Chemistry Proceedings

ISSN: 2673-4583 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/chemproc

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