Advances in endothelial cell lipid metabolism and tumor angiogenesis

Abstract

Angiogenesis is regulated by various signal molecules, which can be found in many pathological processes, such as tumors. Endothelial cells (ECs) are target cells of multiple angiogenesis signaling pathways and play a critical role in angiogenesis. Exploration of ECs' role in angiogenesis has provided multiple research directions for angiogenesis mechanism studies. In recent years, research showed that EC lipid metabolism was closely correlated with angiogenesis. Therefore, we summarized the related regulatory molecules of EC lipid uptake, essential enzymes of lipid metabolism, and endothelium-derived phospholipids during angiogenesis. Moreover, we focused on their relationships with angiogenesis and the role of EC lipid metabolism in tumor angiogenesis.

Keywords

• Endothelial cell
• Angiogenesis
• Lipid metabolism
• Tumor angiogenesis