Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions

Abstract

Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin gene-related peptide (CGRP). CGRP has roles in regulating the function of components of the immune system including T cells, B cells, dendritic cells (DCs), endothelial cells (ECs), and mast cells (MCs).Herein we discuss actions of CGRP in mediating inflammatory and vascular effects in various cutaneous models and disorders.

Keywords

• Calcitonin gene-related peptide
• CGRP
• Skin immunity
• Immunoregulation
• Neurogenic inflammation
• Cutaneous disorders