Nature Communications (Mar 2019)

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

  • James J. Hobson,
  • Amer Al-khouja,
  • Paul Curley,
  • David Meyers,
  • Charles Flexner,
  • Marco Siccardi,
  • Andrew Owen,
  • Caren Freel Meyers,
  • Steve P. Rannard

DOI
https://doi.org/10.1038/s41467-019-09354-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Non-adherence to daily drug regimens is responsible for many negative clinical effects including drug resistance in life-long treatments for HIV. Here, the authors report on a HIV prodrug nanoparticle platform for long-acting sustained release of water-soluble drug compounds following injection.