The functional status of vestibular otolith and conductive pathway in patients with unilateral idiopathic sudden sensorineural hearing loss

Jiali Shen; Jiali Shen; Jiali Shen; Xiaobao Ma; Xiaobao Ma; Xiaobao Ma; Qing Zhang; Qing Zhang; Qing Zhang; Jianyong Chen; Jianyong Chen; Jianyong Chen; Lu Wang; Lu Wang; Lu Wang; Wei Wang; Wei Wang; Wei Wang; Kuan He; Kuan He; Kuan He; Jin Sun; Jin Sun; Jin Sun; Qin Zhang; Qin Zhang; Qin Zhang; Xiangping Chen; Xiangping Chen; Xiangping Chen; Maoli Duan; Maoli Duan; Yulian Jin; Yulian Jin; Yulian Jin; Jun Yang; Jun Yang; Jun Yang

doi:10.3389/fneur.2023.1237516

Frontiers in Neurology (Jul 2023)

The functional status of vestibular otolith and conductive pathway in patients with unilateral idiopathic sudden sensorineural hearing loss

Jiali Shen,
Jiali Shen,
Jiali Shen,
Xiaobao Ma,
Xiaobao Ma,
Xiaobao Ma,
Qing Zhang,
Qing Zhang,
Qing Zhang,
Jianyong Chen,
Jianyong Chen,
Jianyong Chen,
Lu Wang,
Lu Wang,
Lu Wang,
Wei Wang,
Wei Wang,
Wei Wang,
Kuan He,
Kuan He,
Kuan He,
Jin Sun,
Jin Sun,
Jin Sun,
Qin Zhang,
Qin Zhang,
Qin Zhang,
Xiangping Chen,
Xiangping Chen,
Xiangping Chen,
Maoli Duan,
Maoli Duan,
Yulian Jin,
Yulian Jin,
Yulian Jin,
Jun Yang,
Jun Yang,
Jun Yang

Affiliations

Jiali Shen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jiali Shen: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jiali Shen: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xiaobao Ma: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiaobao Ma: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiaobao Ma: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qing Zhang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Qing Zhang: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Qing Zhang: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jianyong Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jianyong Chen: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jianyong Chen: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Lu Wang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Lu Wang: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Lu Wang: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Wei Wang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Wei Wang: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Wei Wang: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Kuan He: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Kuan He: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Kuan He: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jin Sun: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jin Sun: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jin Sun: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qin Zhang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Qin Zhang: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Qin Zhang: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xiangping Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiangping Chen: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiangping Chen: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Maoli Duan: Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden
Maoli Duan: Division of Ear, Nose, and Throat Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
Yulian Jin: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Yulian Jin: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Yulian Jin: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jun Yang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jun Yang: ENT Department, Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jun Yang: ENT Department, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

DOI: https://doi.org/10.3389/fneur.2023.1237516
Journal volume & issue: Vol. 14

Abstract

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BackgroundThe cause of idiopathic sudden sensorineural hearing loss (ISSNHL) remains unknown. It has been found that the functional status of the vestibular otolith is relevant to its prognosis; however, the evaluation of the vestibular otolith (intra-labyrinth) and superior and inferior vestibular nerve pathways (retro-labyrinth) in ISSNHL patients is not well-documented.ObjectiveThis study aimed to investigate the functional status of the vestibular otolith and conductive pathway in patients with unilateral ISSNHL and analyze the correlations between vestibular evoked myogenic potentials (VEMPs) and hearing improvement after treatment.MethodsA total of 50 patients with unilateral ISSNHL underwent a battery of audio-vestibular evaluations, including pure tone audiometry, middle ear function, air-conducted sound-cervical VEMP (ACS-cVEMP), ACS-ocular VEMP (ACS-oVEMP), galvanic vestibular stimulation-cervical VEMP (GVS-cVEMP), and GVS-ocular VEMP (GVS-oVEMP). The results of auditory and VEMPs were retrospectively analyzed.ResultsThe abnormal rates of ACS-cVEMP, ACS-oVEMP, GVS-cVEMP, and GVS-oVEMP in affected ears were 30, 52, 8, and 16%, respectively. In affected ears, the abnormal rate of ACS-oVEMP was significantly higher than that of ACS-cVEMP (p = 0.025), while it was similar between GVS-cVEMP and GVS-oVEMP (p = 0.218). Compared with GVS-cVEMP, affected ears presented with a significantly higher abnormal rate of ACS-cVEMP (p = 0.005), and the abnormal rate of ACS-oVEMP was significantly higher than that of GVS-oVEMP (p < 0.001). No significant difference existed in latency and amplitude between affected and unaffected ears in ACS-VEMPs or GVS-VEMPs (p > 0.05). The abnormal rate of VEMPs in the poor recovery group was significantly higher than that of the good recovery group (p = 0.040). The abnormality percentages of ACS-oVEMP and GVS-oVEMP in the poor recovery group were significantly higher than that of the good recovery group (p = 0.004 and 0.039, respectively). The good hearing recovery rates were 76.47% in the normal VEMPs group, 58.33% in the intra-labyrinth lesion group, and 22.22% in the retro-labyrinth lesion group. Hearing recovery worsened as a greater number of abnormal VEMPs was presented.ConclusionBesides Corti's organ, the impairment of otolithic organs was prominent in patients with ISSNHL. The normal VEMPs group had the highest rate of good recovery, followed by the intra-labyrinth lesion group and the retro-labyrinth lesion group presented with the lowest recovery rate. Abnormalities in ACS-oVEMP and/or GVS-oVEMP were indicators of a poor prognosis.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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