Nature Communications (Sep 2018)
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
- Dina Vojinovic,
- Hieab H. Adams,
- Xueqiu Jian,
- Qiong Yang,
- Albert Vernon Smith,
- Joshua C. Bis,
- Alexander Teumer,
- Markus Scholz,
- Nicola J. Armstrong,
- Edith Hofer,
- Yasaman Saba,
- Michelle Luciano,
- Manon Bernard,
- Stella Trompet,
- Jingyun Yang,
- Nathan A. Gillespie,
- Sven J. van der Lee,
- Alexander Neumann,
- Shahzad Ahmad,
- Ole A. Andreassen,
- David Ames,
- Najaf Amin,
- Konstantinos Arfanakis,
- Mark E. Bastin,
- Diane M. Becker,
- Alexa S. Beiser,
- Frauke Beyer,
- Henry Brodaty,
- R. Nick Bryan,
- Robin Bülow,
- Anders M. Dale,
- Philip L. De Jager,
- Ian J. Deary,
- Charles DeCarli,
- Debra A. Fleischman,
- Rebecca F. Gottesman,
- Jeroen van der Grond,
- Vilmundur Gudnason,
- Tamara B. Harris,
- Georg Homuth,
- David S. Knopman,
- John B. Kwok,
- Cora E. Lewis,
- Shuo Li,
- Markus Loeffler,
- Oscar L. Lopez,
- Pauline Maillard,
- Hanan El Marroun,
- Karen A. Mather,
- Thomas H. Mosley,
- Ryan L. Muetzel,
- Matthias Nauck,
- Paul A. Nyquist,
- Matthew S. Panizzon,
- Zdenka Pausova,
- Bruce M. Psaty,
- Ken Rice,
- Jerome I. Rotter,
- Natalie Royle,
- Claudia L. Satizabal,
- Reinhold Schmidt,
- Peter R. Schofield,
- Pamela J. Schreiner,
- Stephen Sidney,
- David J. Stott,
- Anbupalam Thalamuthu,
- Andre G. Uitterlinden,
- Maria C. Valdés Hernández,
- Meike W. Vernooij,
- Wei Wen,
- Tonya White,
- A. Veronica Witte,
- Katharina Wittfeld,
- Margaret J. Wright,
- Lisa R. Yanek,
- Henning Tiemeier,
- William S. Kremen,
- David A. Bennett,
- J. Wouter Jukema,
- Tomas Paus,
- Joanna M. Wardlaw,
- Helena Schmidt,
- Perminder S. Sachdev,
- Arno Villringer,
- Hans Jörgen Grabe,
- W T Longstreth,
- Cornelia M. van Duijn,
- Lenore J. Launer,
- Sudha Seshadri,
- M Arfan Ikram,
- Myriam Fornage
Affiliations
- Dina Vojinovic
- Department of Epidemiology, Erasmus MC University Medical Center
- Hieab H. Adams
- Department of Epidemiology, Erasmus MC University Medical Center
- Xueqiu Jian
- The University of Texas Health Science Center at Houston Institute of Molecular Medicine
- Qiong Yang
- Department of Biostatistics, School of Public Health, Boston University
- Albert Vernon Smith
- Icelandic Heart Association
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Nicola J. Armstrong
- Mathematics and Statistics, Murdoch University
- Edith Hofer
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Yasaman Saba
- Gottfried Schatz research center, Institute for Molecular biology and biochemistry
- Michelle Luciano
- Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
- Manon Bernard
- Research Institute of the Hospital for Sick Children
- Stella Trompet
- Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center
- Jingyun Yang
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Nathan A. Gillespie
- Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University
- Sven J. van der Lee
- Department of Epidemiology, Erasmus MC University Medical Center
- Alexander Neumann
- Department of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Center Rotterdam
- Shahzad Ahmad
- Department of Epidemiology, Erasmus MC University Medical Center
- Ole A. Andreassen
- Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo
- David Ames
- National Ageing Research Institute
- Najaf Amin
- Department of Epidemiology, Erasmus MC University Medical Center
- Konstantinos Arfanakis
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Mark E. Bastin
- Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
- Diane M. Becker
- Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine
- Alexa S. Beiser
- Department of Biostatistics, School of Public Health, Boston University
- Frauke Beyer
- Department of Neurology, Max Planck Institute of Cognitive and Brain Sciences
- Henry Brodaty
- Centre for Healthy Brain Ageing, School of Psychiatry, UNSW
- R. Nick Bryan
- The University of Texas at Austin Dell Medical School
- Robin Bülow
- Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald
- Anders M. Dale
- Department of Cognitive Science, University of California, San Diego
- Philip L. De Jager
- Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
- Charles DeCarli
- Department of Neurology and Center for Neuroscience, University of California
- Debra A. Fleischman
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Rebecca F. Gottesman
- Department of Neurology, Johns Hopkins School of Medicine
- Jeroen van der Grond
- Department of Radiology, Leiden University Medical Center
- Vilmundur Gudnason
- Icelandic Heart Association
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- David S. Knopman
- Department of Neurology, Mayo Clinic
- John B. Kwok
- School of Medical Sciences, University of New South Wales
- Cora E. Lewis
- The University of Alabama at Birmingham School of Medicine
- Shuo Li
- Department of Biostatistics, School of Public Health, Boston University
- Markus Loeffler
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Oscar L. Lopez
- Department of Neurology, University of Pittsburgh
- Pauline Maillard
- Department of Neurology and Center for Neuroscience, University of California
- Hanan El Marroun
- Department of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Center Rotterdam
- Karen A. Mather
- Centre for Healthy Brain Ageing, School of Psychiatry, UNSW
- Thomas H. Mosley
- The University of Mississippi Medical Center
- Ryan L. Muetzel
- Department of Epidemiology, Erasmus MC University Medical Center
- Matthias Nauck
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
- Paul A. Nyquist
- Department of Neurology, Johns Hopkins School of Medicine
- Matthew S. Panizzon
- Department of Psychiatry, University of California, San Diego
- Zdenka Pausova
- Research Institute of the Hospital for Sick Children
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Ken Rice
- Department of Biostatistics, University of Washington
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Natalie Royle
- Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
- Claudia L. Satizabal
- Framingham Heart Study
- Reinhold Schmidt
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Peter R. Schofield
- School of Medical Sciences, University of New South Wales
- Pamela J. Schreiner
- University of Minnesota School of Public Health
- Stephen Sidney
- Kaiser Permanente Northern California Division of Research
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow
- Anbupalam Thalamuthu
- Centre for Healthy Brain Ageing, School of Psychiatry, UNSW
- Andre G. Uitterlinden
- Department of Internal Medicine, Erasmus MC University Medical Center
- Maria C. Valdés Hernández
- Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
- Meike W. Vernooij
- Department of Epidemiology, Erasmus MC University Medical Center
- Wei Wen
- Centre for Healthy Brain Ageing, School of Psychiatry, UNSW
- Tonya White
- Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center
- A. Veronica Witte
- Department of Neurology, Max Planck Institute of Cognitive and Brain Sciences
- Katharina Wittfeld
- German Center for Neurodegenerative Diseases (DZNE)
- Margaret J. Wright
- Queensland Brain Institute, University of Queensland
- Lisa R. Yanek
- Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine
- Henning Tiemeier
- Department of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Center Rotterdam
- William S. Kremen
- Department of Psychiatry, University of California, San Diego
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Tomas Paus
- Rotman Research Institute, Baycrest
- Joanna M. Wardlaw
- Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh
- Helena Schmidt
- Gottfried Schatz research center, Institute for Molecular biology and biochemistry
- Perminder S. Sachdev
- Centre for Healthy Brain Ageing, School of Psychiatry, UNSW
- Arno Villringer
- Department of Neurology, Max Planck Institute of Cognitive and Brain Sciences
- Hans Jörgen Grabe
- German Center for Neurodegenerative Diseases (DZNE)
- W T Longstreth
- Department of Epidemiology, University of Washington
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus MC University Medical Center
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health
- Sudha Seshadri
- Framingham Heart Study
- M Arfan Ikram
- Department of Epidemiology, Erasmus MC University Medical Center
- Myriam Fornage
- The University of Texas Health Science Center at Houston Institute of Molecular Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06234-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
An increase in the volume of the brain lateral ventricles is a sign of normal aging, but can also be associated with neurological and psychiatric disorders. Here, Vojinovic et al. identify seven genetic loci in a GWA study for ventricular volume in 23,500 individuals and find correlation with thalamus volume.
